PRODUCT CODE:

131147

Acetic Anhydride (Reag. Ph. Eur.) PA-ACS-ISO

C₄H₆O₃

M.= 102,09	CAS [108-24-7]	EINECS 203-564-8
NC 2915 24 00

PHYSICAL DATA: Clear , colourless liquid ·Decomposes with water ·Lacrimator ·D at 20/4: 1.082 ·M. P.: -73 ºC · B. P.: 136-142ºC ·n²⁰/D: 1,3903 ·Flash P.: 54 °C ·Ign. T.: 389 ºC ·Vap. press. at 20 °C 5 hPa ·Expl. limit 2 - 10,2 in vol % ·
APPLICATIONS: Analytical reagent: USP 29 · BP 2005 · Ph. Eur. 5.0 · For the determination of cholesterol ·
Synthesis reagent: For acetylation reactions ; H.W. Pinnick et al., J. Org. Chem., 48 , 1765 (1983) ; H. Katayama, M. Ohkoshi, Synthesis, 962 (1982) · Cleavage of ethers ; R. P. Sharmo et al., Tetrahedron Lett., 24 , 1189 (1983) · Reagent for inducing the Pummerer rearrangement of sulphoxides to a-acetoxysulphides ; J. Org. Chem., 33 , 4150 (1968). Review ; Adv. Org. Chem., 6 , 356 (1969) · In sulphuric acid , is a reagent for the oxidative aromatisation of substituted cyclohexanones to phenols , J. Org.Chem., 39 , 2126 (1974) · Symilarly , 2-alkylcyclohexane-1,3-diones are converted to 2-alkylresorcinols ; J. Org. Chem., 39 , 3696 (1974) · In combination with sodium acetate, is the classical reagent for the Perkin reaction for the conversion of aromatic aldehydes cinnamic acids ; Org. Synth. Coll. Vol. 1 , 398 (1941) ; Review : Org. Ract. , 1 , 210 (1942) · Used in heterocyclic synthesis ; Review : J. Heterocycl. Chem., 13 , 179 (1976) ·
BIBLIOGRAPHY: Merck Index 12 , 53 13 , 57 · Sax AAX 500 · Safety 2 , 18 A · Römpp 8 , 1186 · Kühn-Birett E 10 · Beilstein 2 , 166 I , 75 II , 170 III , 371 IV , 94 · BRN: 385737 · Ullmann (5.) 1 , 65 · Fieser 1 , 3 2 , 7 5 , 3 6 , 1 7 , 1 8 , 1 9 , 1 11 , 1 · ACS IX , 119 X , 129 · ISO 6353/3-1987 R - 41 , 2 ·

HAZARDOUS: E.C.: 607-008-00-9 · RTECS: AK 1925000 · LD₅₀ oral rat 1780 mg/Kg · LD₅₀ skn rbt 4000 mg/Kg · LC₅₀ ihl rat 1000 ppm/4h · VLA-ED: 21 mg/m³ ·

R: 10-20/22-34
S: 26-36/37/39-45

TRANSPORT REGULATIONS: UN: 1715 · ADR: 8/II · IMDG: 8/II · IATA: 8/II · PAX: 809 · CAO: 813·
WEIGHT/VOLUME INFORMATION: 1lX1,08kg 1kgX0,93l
OBSERVATIONS: Product controlled as a drug precursor ·

SPECIFICATIONS:

Minimum assay	99 %
MAXIMUM LIMIT OF IMPURITIES
Non-volatile matter	0,003 %
Reducing substances to KMnO₄	p/t.
Chloride (Cl)	0,0005 %
Phosphate (PO₄)	0,001 %
Sulphate (SO₄)	0,0005 %
Heavy metals (as Pb)	0,0002 %
Metals by ICP [mg/Kg (ppm)]
Ag	0,1
Al	0,05
As	0,1
Au	0,1
B	0,05
Ba	0,1
Bi	0,05
Ca	5
Cd	0,02
Co	0,02
Cr	0,02
Cu	0,02
Fe	0,1
Ga	0,05
Ge	0,02
Hg	0,1
In	0,05
K	0,1
Li	0,02
Mg	0,1
Mn	0,02
Mo	0,02
Na	0,5
Ni	0,02
Pb	0,1
Pt	0,1
Sb	0,02
Si	0,1
Sn	0,05
Sr	0,05
Ti	0,05
Tl	0,02
V	0,05
Zn	0,1
Zr	0,02