PRODUCT CODE:

131156

Aniline (Reag. Ph. Eur.) PA-ACS

C₆H₇N

M.= 93,13	CAS [62-53-3]	EINECS 200-539-3
NC 2921 41 00

SYNONYMS: Phenylamine ·Benzenamine ·
PHYSICAL DATA: Clear , colourless to yellowish liquid ·Solubility in water at 20 ºC 34 g/l ·D at 20/4: 1,0217 ·M. P.: -6,3 ºC ·B. P.: 184 ºC ·n²⁰/D: 1,5863 ·Flash P.: 76 ºC ·Ign. T.: 530 ºC ·Vap. press at 20 °C 3 hPa ·D. M. at 20 °C 1,55 Debye ·Dielec. constant at 20 ºC 6,8 ·Heat vap. at 184 ºC 508 KJ/Kg ·Satur. conc. at 20 °C 2 g/m³·Expl. limit 1,3 - 11 in vol % ·Water absortion at 30 ºC 54 % (p/p) ·
APPLICATIONS: Analytical reagent: RFE · USP 25 · BP · Ph. Eur. IV ·
Synthesis reagent: Skraup synthesis of quinolines ; Org. React., 7 , 59 (1953) · Synthesis of isatin ; Org. Synth. Coll. Vol., 1 , 327 (1941) · Japp-Klingemann reaction , preparation of 1-alkylphenylhydrazines , Synth. Commun., 18 , 1225 (1988) · Fischer indole synthesis from phenylhydrazones prepared by Japp-Klingemann reaction ; Chem. Rev., 69 , 227 (1969) · Conversion of arylamines to halides: Gatterman and Sandmeyer reactions ; Reviews Chem. Rev, 40 , 251 (1947) ; 42 , 213 (1948). Angew. Chem., 65 , 255 (1953) ; Q. Rev. Chem. Soc., 6 , 358 (1952) · Arylamines can be deaminated by reduction of the diazonium salts ; Org. React., 2 , 262 (1944 ) · Arenediazonium salts coupe with actived alkenes in the Meerwein reaction , Org. React., 11 , 189 (1960) ; 24 , 225 (1976) ·
BIBLIOGRAPHY: Merck Index 12 , 696 13 , 661 · Sax AOQ 000 · Safety 2 , 270 A · Kühn-Birett A 73 · Fieser 6 , 21 · Beilstein 12 , 59 I , 131 II , 44 III , 217 IV , 223 ·BRN: 605631 · Ullmann (5.) 2 , 303 · ACS IX , 165 X , 177 ·

HAZARDOUS: E.C.: 612-008-00-7 · RTECS: BW 6650000 · LD₅₀ orl rat. 250 mg/Kg · LD₅₀ skn rbt 820 mg/Kg · LD L₀ orl rat 500 mg/Kg · LC₅₀ ihl rat. 250 ppm/4h · LC₅₀ ihl mus 175 ppm/4h ·VLA-ED: 7,7 mg/m³ ·

R: 23/24/25-40-41-43-48/23/24/25-68-50
S: 26-27-36/37/39-45-46-61-63

TRANSPORT REGULATIONS: UN: 1547 · ADR: 6.1/II · IMDG: 6.1/II · IATA: 6.1/II · PAX: 609 · CAO: 611·
WEIGHT/VOLUME INFORMATION: 1lX1,022kg 1kgX0,978l

SPECIFICATIONS:

Minimum assay (G.C.)	99,5 %
Identity	IR p/t.
Density at 20/4	1,021-1,023
MAXIMUM LIMIT OF IMPURITIES
APHA colour	250
Residue on ignition	0,005 %
Chlorobenzene (G.C.)	0,01 %
Hydrocarbons	p/t.
Nitrobenzene (G.C.)	0,001 %
Water (H₂O)	0,1 %
Ca	0,00005 %
Cd	0,000005 %
Co	0,000002 %
Cr	0,000002 %
Cu	0,000002 %
Fe	0,00001 %
Mg	0,00001 %
Mn	0,000002 %
Ni	0,000002 %
Pb	0,00001 %
Zn	0,00001 %