PRODUCT CODE:

363317

Trifluoroacetic Acid (UV) PAI

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C₂HF₃O₂

M.= 114,02	CAS [76-05-1]	EINECS 200-929-3
NC 2915 90 80

SYNONYMS: TFA ·
PHYSICAL DATA: Clear , colourless liquid ·Miscible with water ·Hygroscopic ·D at 20/4: 1,489 ·M. P.: -15,2 °C ·B. P.: 72,4 °C ·n²⁰/D: 1,300 ·Vap. press. at 25 °C 142 hPa ·Heat evap. at 72 °C: 292 KJ/Kg ·Viscosty at 20 °C 0,91 mPas ·Dielec. constant at 25 °C 42,1 ·
APPLICATIONS: Analytical reagent: RFE I ·USP 25 ·BP 2000 · Ph. Eur. IV ·  Reagent for the sequencing of proteins ; M. W. Hunkapiller et al. , Biochemistry ,17 , 2124 (1978) ; M. W. Hunkapiller et al. , Science , 207 , 523 (1980) ; R. M. Hewick et al. , J. Biol. Chem. , 15 , 7990 (1981) ·
Synthesis reagent: With sodium nitrate , is a source of the nitronium ion which nitrates benzene or toluene in quantitative yield ; J. Org. Chem. , 39 , 3936 (1974) ·Used for polyene cyclisations ; W. S. Johnson et al. , Tetrahedron Lett. , 2549 (1978) ·Sodium nitrite in trifluoroacetic acid has been used for the cleavage of tosylhydrazones ; Synthesis , 207 (1979) ·Used as a catalyst in the Cope rearrangement ; Tetrahedron Lett , 22 , 1583 (1981) · Catalyse the loss of nitrogen from a -diazoketones ; Tetrahedron , 37 , 2407 (1981) ·Used as a catalyst in the Claisen allyl ether rearrangement ; J. Chem. Soc. Chem. Comumm. , 1120 (1982) ·Carrying out the Curtis rearrangement of acyl azides in trifluoroacetic acid leads directly to the trifluoroacetamide , which can be readily hydrolised to the free amine ; Synthesis , 38 (1983) ·Selective cleavage of ethers in the presence of ester functions ; M. V. Bhatt , S. U. Kulkami , Synthesis , 249 (1983) ·Used in the deacylation of aromatic carboxylic acids ; T. Keumi et al. , Synthesis , 979 (1985) ·Used for the successful diazotisation of weakly basic arylamines ; Synthesis , 566 (1988) ·
BIBLIOGRAPHY: Merck Index 12 , 9812 13 , 9754 ·Sax TKA 250 ·Safety 2 , 3439 A ·Kühn-Birett T 55 ·Beilstein 2 , II , 186 III , 426 IV , 458 ·BRN: 742035 ·Fieser 1 , 1219 2 , 433 3 , 305 4 , 530 5 , 695 7 , 388 8 , 503 9 , 483 10 , 41812 , 529 14 , 322 15 , 338 ·

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HAZARDOUS: E.C.: 607-091-00-1 · RTECS: AJ 9625000 · LD₅₀ orl rat 200 mg/Kg ·

R: 20-35-52/53 S: 9-26-27-28a-45-61

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TRANSPORT REGULATIONS: UN: 2699 · ADR: 8/I · IMDG: 8/I · IATA: 8/I · PAX: 807 · CAO: 809·
WEIGHT/VOLUME INFORMATION: 1lX1,489kg     1kgX0,671l

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SPECIFICATIONS:

Minimum assay (Acidim.)	99,8 %
Identity	IR p/t.
MAXIMUM LIMIT OF IMPURITIES
APHA colour	10
Non-volatile matter	0,001 %
Water (H2O)	0,1 %
UV Spectrum (1 cm cell; Ref.: water)

l (nm)	260  (Cut off)	305	320	325-450
A (AU)	1,000	0,301	0,097	0,046
T (%)	10	50	80	90

Microfiltered product (0,2 mm) and bottled under nitrogen atmosphere.
For critical jobs, purge with nitrogen.